Oral Administration of GW788388, an Inhibitor of Transforming Growth Factor Beta Signaling, Prevents Heart Fibrosis in Chagas Disease Full Text
PLoS Neglected Tropical Diseases, 06/14/2012
de Oliveira FL et al. – This suggests that this class of molecules may represent a new therapeutic tool for acute and chronic Chagas disease that warrants further pre–clinical exploration. Administration of TGFß inhibitors during chronic infection in mouse models should be further evaluated, and future clinical trials should be envisaged.