Mitochondrial uncouplers inhibit hepatic stellate cell activation

BMC Gastroenterology, 06/14/2012

Mild mitochondrial uncoupling inhibits culture–induced hepatic stellate cell (HSC) activation and their response to pro–fibrogenic cytokines like TGF–beta. These results therefore suggest mitochondrial uncoupling of HSCs as a strategy to reduce progression of liver fibrosis.

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