The association of insulin resistance and carotid atherosclerosis with thigh and calf circumference in patients with type 2 diabetes Full Text
Cardiovascular Diabetology, 06/11/2012
Park JS et al. – Thigh and calf circumference were correlated with insulin resistance and carotid atherosclerosis, and thigh circumference was independently associated with insulin resistance and carotid atherosclerosis in patients with type 2 diabetes.Methods
- A total of 4,427 subjects with type 2 diabetes were enrolled in this study.
- Insulin sensitivity was assessed according the rate constant for plasma glucose disappearance (Kitt) determined via the short insulin tolerance test.
- Biochemical and anthropometric profiles were measured according to a standardized protocol.
- Visceral fat thickness and carotid intima media thickness (IMT) were measured by ultrasonography.
- Insulin sensitivity index (Kitt) was significantly correlated with weight adjusted thigh and calf circumference.
- Thigh circumference was inversely associated with IMT in men and women and calf circumference was negatively correlated with IMT in women.
- Multiple stepwise regression analysis revealed that thigh circumference was independently correlated with insulin sensitivity index (Kitt) and IMT.
- Furthermore, in multivariate logistic regression analysis, thigh circumference was an independent determinant factor for carotid atherosclerosis in patients with type 2 diabetes even after adjusting for other cardiovascular risk factors.