Vitamin D status, incident diabetes and prospective changes in glucose metabolism in older subjects: The Hoorn study
Nutrition, Metabolism & Cardiovascular Diseases, 06/14/2012

Pilz S et al. – In this study among the older population authors observed no significant association of baseline 25(OH)D with glucose metabolism and incident diabetes. They found, however, a non–significant trend towards an inverse association of 25(OH)D with prospective changes in HbA1c that deserves further investigations.

• Authors examined a subsample from the population based Hoorn study among older men and women.
• Physical examinations were performed from 2000 to 2001 and included measurements of 25(OH)D.
• Glucose tolerance tests and HbA1c measurements were performed at baseline and at a follow–up between 2007 and 2009.
• They included 351 study participants (51% females; 67.9±5.7 years).
• Baseline 25(OH)D levels were 56.7±18.8nmol/L and follow–up visits were performed after 7.5±0.5 years.
• Among 280 study participants without diabetes at baseline authros recorded 45 cases of incident diabetes.

• There was no significant association of 25(OH)D with the incidence of diabetes and with fasting and 2h postload glucose levels at follow–up.
• In analyses adjusted for age, sex, and baseline HbA1c there was, however, a significant association of 25(OH)D with follow–up HbA1c levels (beta coefficient=–0.085, p=0.085).
• This association was attenuated after further adjustments for BMI (beta coefficient=–0.079, p=0.064).