The Cytoskeletal Adaptor Protein IQGAP1 Regulates TCR-Mediated Signaling and Filamentous Actin Dynamics
The Journal of Immunology, 06/08/2012
Gorman JA et al. – The authors found that discrete regions of IQGAP1 regulated cellular activation and F–actin accumulation. The data suggest that IQGAP1 acts as a dual negative regulator in T cells, limiting both TCR–mediated activation kinetics and F–actin dynamics via distinct mechanisms.