Innate IFNs and Plasmacytoid Dendritic Cells Constrain Th2 Cytokine Responses to Rhinovirus: A Regulatory Mechanism with Relevance to Asthma
The Journal of Immunology, 06/08/2012
Pritchard AL et al. – Depletion of CD1c+ dendritic cells did not alter cytokine synthesis. In healthy humans, plasmacytoid dendritic cells (pDC) and the IFN–αβ they secrete selectively constrain Th2 cytokine synthesis following rhinoviruses (RV) exposure in vitro. This important regulatory mechanism may be lost in asthma; deficient IFN–αβ synthesis and/or pDC dysfunction have the potential to contribute to asthma exacerbations during RV infections.