Identification of seven serum microRNAs from a genome-wide serum miRNA expression profile as potential noninvasive biomarkers for malignant astrocytomas
International Journal of Cancer, 06/12/2012
Yang C et al. – The identified miRNAs also exhibited a global decrease in tumor tissues relative to normal tissues. Furthermore, these miRNAs in serum were markedly elevated after operation. In addition, some of these serum miRNAs were significantly different between malignant and benign cases, astrogliosis and other primary brain tumors. The seven serum miRNAs identified in the study hold potential as noninvasive biomarker for malignant astrocytomas.