Analysis of Hepatitis B Virus Drug-Resistant Mutant Haplotypes by Ultra-Deep Pyrosequencing

Clinical Microbiology and Infection, 06/04/2012

Entecavir–resistance mutations were found to be co–located on the same viral genome in all 20 patients displaying virological breakthrough or reduced susceptibility to entecavir. In conclusion, UDPS was not only sensitive and accurate in identifying drug–resistance mutations of HBV but also enabled haplotype analysis of the mutants. This method may offer significant advantages in explaining and predicting the responses of patients with HBV to antiviral therapy.

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