An open-label pilot study of aripiprazole for male and female Veterans with chronic post-traumatic stress disorder who respond suboptimally to antidepressants
International Clinical Psychopharmacology,  Clinical Article

Youssef NA et al. – Emerging data suggest that second–generation antipsychotics such as aripiprazole may be effective in the treatment of post–traumatic stress disorder (PTSD). However, few clinical trials have used aripiprazole in PTSD, and data are limited on its use in Veterans with PTSD.

Methods
  • Ten individuals (five men and five women) meeting the Diagnostic and statistical manual of mental disorders, 4th ed., PTSD criteria participated in this 12–week, open–label, flexibly dosed monotherapy trial.
  • The dose range of aripiprazole was 5–30 mg/day, titrated to tolerability and clinical response.
  • The primary outcome measure was the Clinician–Administered PTSD Scale.
  • Additional outcomes included the Short PTSD Rating Interview, the Treatment Outcome PTSD Scale (Top–8), the Davidson Trauma Scale, the Positive and Negative Syndrome Scale, the Beck Depression Inventory–Fast Screen, and Clinical Global Impressions–Improvement.

Results
  • Eight participants completed the study, and aripiprazole was generally well tolerated and associated with a significant improvement in PTSD symptoms, as measured by the Clinician–Administered PTSD Scale (primary outcome measure) and by the Short PTSD Rating Interview, the Treatment Outcome PTSD Scale, and the Davidson Trauma Scale.
  • An improvement was also observed on all three Positive and Negative Syndrome Scale subscales and the Beck Depression Inventory–Fast Screen, and the average Clinical Global Impressions–Improvement ratings indicated that patients were ‘much improved’.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Internal Medicine

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Internal Medicine Articles

1 Sweetened carbonated beverage consumption and cancer risk: Meta-analysis and review European Journal of Cancer Prevention, August 1, 2014    Evidence Based Medicine    Review Article

2 Triglycerides and cardiovascular disease The Lancet, August 19, 2014    Evidence Based Medicine    Clinical Article

3 Effects of intensive glycaemic control on ischaemic heart disease: analysis of data from the randomised, controlled ACCORD trial The Lancet, August 5, 2014    Evidence Based Medicine    Clinical Article

4 Global sodium consumption and death from cardiovascular causes New England Journal of Medicine, August 15, 2014    Evidence Based Medicine    Clinical Article

5 Effect of BCG vaccination against Mycobacterium tuberculosis infection in children: systematic review and meta-analysis BMJ, August 20, 2014    Evidence Based Medicine    Clinical Article

6 A very low carbohydrate, low saturated fat diet for type 2 diabetes management: a randomized trial Diabetes Care, July 31, 2014    Clinical Article

7 Corticosteroid treatment for community-acquired pneumonia - the STEP trial: study protocol for a randomized controlled trial Full Text Trials, July 16, 2014    Free full text    Evidence Based Medicine    Clinical Article

8 Obesity is a risk factor for significant carotid atherosclerosis in patients aged 39 to 55 years Angiology, July 18, 2014    Evidence Based Medicine    Clinical Article

9 Perioperative atrial fibrillation and the long-term risk of ischemic stroke JAMA, August 26, 2014    Evidence Based Medicine    Clinical Article

10 Changes in circulating leptin levels during acute stress and associations with craving in abstinent smokers: A preliminary investigation Psychoneuroendocrinology, June 20, 2014    Clinical Article

11 A randomized trial of epidural glucocorticoid injections for spinal stenosis New England Journal of Medicine, July 7, 2014    Evidence Based Medicine    Clinical Article

12 QTc changes after meal intake: sex differences and correlates Journal of Electrocardiology, August 27, 2014    Clinical Article

13 Being overweight or obese and risk of developing rheumatoid arthritis among women: A prospective cohort study Annals of Rheumatic Diseases, August 25, 2014    Evidence Based Medicine    Clinical Article

14 Statins and physical activity in older men the osteoporotic fractures in men study JAMA Internal Medicine, June 12, 2014    Evidence Based Medicine    Clinical Article

15 Screening pelvic examinations in asymptomatic, average-risk adult women: An evidence report for a clinical practice guideline from the American college of physicians Annals of Internal Medicine, July 2, 2014    Evidence Based Medicine    Clinical Article

16 Relationship between tea consumption and pancreatic cancer risk: A meta-analysis based on prospective cohort studies and case-control studies European Journal of Cancer Prevention, August 1, 2014    Evidence Based Medicine    Clinical Article

17 Risk of dementia among patients with asthma: a nationwide longitudinal study Journal of the American Medical Directors Association, August 1, 2014    Clinical Article

18 Impact of graduated compression stockings on the prevention of post-thrombotic syndrome - results of a randomized controlled trial Phlebology, August 20, 2014    Evidence Based Medicine    Clinical Article

19 Fruit and vegetable consumption and mortality from all causes, cardiovascular disease, and cancer: systematic review and dose-response meta-analysis of prospective cohort studies BMJ, August 1, 2014    Evidence Based Medicine    Review Article    Clinical Article

20 Screening and prostate cancer mortality: Results of the European Randomised Study of Screening for Prostate Cancer (ERSPC) at 13 years of follow-up The Lancet, August 8, 2014    Evidence Based Medicine    Clinical Article

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicinemore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close