An open-label pilot study of aripiprazole for male and female Veterans with chronic post-traumatic stress disorder who respond suboptimally to antidepressants
International Clinical Psychopharmacology,  Clinical Article

Youssef NA et al. – Emerging data suggest that second–generation antipsychotics such as aripiprazole may be effective in the treatment of post–traumatic stress disorder (PTSD). However, few clinical trials have used aripiprazole in PTSD, and data are limited on its use in Veterans with PTSD.

Methods
  • Ten individuals (five men and five women) meeting the Diagnostic and statistical manual of mental disorders, 4th ed., PTSD criteria participated in this 12–week, open–label, flexibly dosed monotherapy trial.
  • The dose range of aripiprazole was 5–30 mg/day, titrated to tolerability and clinical response.
  • The primary outcome measure was the Clinician–Administered PTSD Scale.
  • Additional outcomes included the Short PTSD Rating Interview, the Treatment Outcome PTSD Scale (Top–8), the Davidson Trauma Scale, the Positive and Negative Syndrome Scale, the Beck Depression Inventory–Fast Screen, and Clinical Global Impressions–Improvement.

Results
  • Eight participants completed the study, and aripiprazole was generally well tolerated and associated with a significant improvement in PTSD symptoms, as measured by the Clinician–Administered PTSD Scale (primary outcome measure) and by the Short PTSD Rating Interview, the Treatment Outcome PTSD Scale, and the Davidson Trauma Scale.
  • An improvement was also observed on all three Positive and Negative Syndrome Scale subscales and the Beck Depression Inventory–Fast Screen, and the average Clinical Global Impressions–Improvement ratings indicated that patients were ‘much improved’.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Internal Medicine

See All >> Messages include industry-sponsored communications and special communications from MDLinx

<

Most Popular Internal Medicine Articles

1 Acupuncture for chronic knee pain: a randomized clinical trial JAMA, October 1, 2014    Evidence Based Medicine    Clinical Article

2 Calcium and phosphorus intake and prostate cancer risk: A 24-y follow-up study American Journal of Clinical Nutrition, November 26, 2014    Clinical Article

3 Effects of tea intake on blood pressure: A meta-analysis of 21 randomized controlled trials JACC - Journal of the American College of Cardiology, October 22, 2014    Clinical Article

4 Vitamin D and Calcium Supplementation to Prevent Fractures in Adults: U.S. Preventive Services Task Force Recommendation Statement Full Text Annals of Internal Medicine, February 26, 2013    Free full text    Clinical Guideline

5 Aggressive risk factor reduction study for atrial fibrillation and implications for the outcome of ablation: The ARREST-AF cohort study JACC - Journal of the American College of Cardiology, December 3, 2014    Evidence Based Medicine    Clinical Article

6 The impact of phlebotomy in nonalcoholic fatty liver disease: A prospective randomized controlled trial Hepatology, December 24, 2014    Clinical Article

7 Sweetened carbonated beverage consumption and cancer risk: Meta-analysis and review European Journal of Cancer Prevention, August 1, 2014    Evidence Based Medicine    Review Article

8 Liberal versus restrictive blood transfusion strategy: 3-year survival and cause of death results from the FOCUS randomised controlled trial The Lancet, December 11, 2014    Evidence Based Medicine    Clinical Article

9 Cytisine versus nicotine for smoking cessation New England Journal of Medicine, December 18, 2014    Evidence Based Medicine    Clinical Article

10 P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study The Lancet, December 2, 2014    Evidence Based Medicine    Clinical Article

11 Avoidance of sun exposure is a risk factor for all-cause mortality: results from the MISS cohort Journal of Internal Medicine, April 22, 2014    Evidence Based Medicine    Clinical Article

12 Effect of metformin on left ventricular function after acute myocardial infarction in patients without diabetes: The GIPS-III randomized clinical trial Full Text JAMA, April 16, 2014    Free full text    Evidence Based Medicine    Clinical Article

13 Tea consumption and leukemia risk: A meta-analysis Tumor Biology, February 12, 2014    Evidence Based Medicine    Clinical Article

14 Adherence to the Mediterranean diet is associated with the severity of non-alcoholic fatty liver disease Clinical Nutrition, August 11, 2014    Clinical Article

15 Coffee consumption and risk of nonaggressive, aggressive and fatal prostate cancer - A dose-response meta-analysis Full Text Annals of Oncology, December 2, 2013    Free full text    Evidence Based Medicine    Clinical Article

16 Sodium zirconium cyclosilicate in hyperkalemia New England Journal of Medicine, November 26, 2014    Evidence Based Medicine    Clinical Article

17 Resveratrol levels and all-cause mortality in older community-dwelling adults JAMA Internal Medicine, May 13, 2014    Evidence Based Medicine    Clinical Article

18 Factor XI antisense oligonucleotide for prevention of venous thrombosis New England Journal of Medicine, December 10, 2014    Evidence Based Medicine    Clinical Article

19 Aspirin in type 2 diabetes, a randomised controlled study: effect of different doses on inflammation, oxidative stress, insulin resistance and endothelial function International Journal of Clinical Practice, December 27, 2013    Clinical Article

20 Liberal versus restrictive blood transfusion strategy: 3-year survival and cause of death results from the FOCUS randomised controlled trial The Lancet, December 19, 2014    Evidence Based Medicine    Clinical Article

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicinemore

Make smarter career moves with less time.

Sign up for our free job placement service today and have a dedicated career consultant help locate the right physician job for you!
Click Here for more information.

Get Started Now!

Free-of-charge, no obligation.

Terms and Conditions For M3 Career Consult

By registering with the M3 Career Consult service you authorize M3 USA Corporation to represent you in your job search. The following is a summary of the terms of our service and our mutual obligations to help you find a job:

  • You designate M3 to act as your agent and represent you in your job search;
  • You will not pay us for this service
  • You will advise us of any companies or positions to which you apply or have applied;
  • You will advise us if you believe you are not capable of performing a position for which we submit you, or for which you interview;
  • You will keep all information we provide you about companies or positions strictly confidential;
  • You will promptly provide us with information we request of you;
  • You will make yourself reasonably available for phone, video and in-person conversations and interviews;
  • You will be truthful in all of your communications with us; and
  • You will advise us if anything above changes.
 

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List