p28GANK Prevents Degradation of Oct4 and Promotes Expansion of Tumor-Initiating Cells in Hepatocarcinogenesis
Gastroenterology, 06/04/2012
Qian YW et al. – p28GANK(Gankyrin) activates and maintains liver T–ICs in Hepatocellular carcinoma (HCC) by preventing degradation of Oct4. Inhibitors of p28GANK might therefore be developed to inactivate tumor–initiating cells (T–ICs)s and slow tumor progression.



