Sonographic criteria for therapy follow-up in the course of ultrasound-guided intra-articular injections of hyaluronic acid in hand osteoarthritis
European Journal of Radiology,  Clinical Article

Klauser AS et al. – In this study, the authors demonstrate the meaningfulness of sonographic evaluation criteria including measurements of joint capsule distension and Power–Doppler ultrasound (US) (PDUS) vascularization, both significantly correlating with the decrease of pain, during the therapy follow–up of US–guided intra–articular hyaluronic acid (HA)–injections in patients with hand osteoarthritis (OA).

Methods
  • Thirty–three patients (28 females/5 males), with hand OA in 78 joints, were included in this study.
  • Patients underwent sonographic evaluation at baseline and consecutively for 4 weeks at weekly US–guided intra–articular injections of HA (Hyalgan).
  • Measurements of joint thickening and joint inflammation were performed with Grey–scale and semi–quantitative Power–Doppler US (PDUS).
  • Sonographic values were correlated with weekly patients self–assessment of pain for each treated joint.

Results
  • The mean (SD) patients self–assessment of pain statistically significantly (p<0.0001) decreased from the first [68.3(22.3)] to the last week [37.3(30.34)].
  • A steady pain relief could be noticed in 67 (86%) of all treated joints.
  • Over the whole observation period, the mean (SD) joint thickening of all joints markedly decreased from 15.6mm (5.3) to 13.1mm (6.4) (p<0.0001).
  • The PDUS–score before initiation of HA treatment was statistically significantly higher than at the end of therapy (p<0.0001).
  • The decrease in pain statistically significantly correlated with the decrease of joint thickening and PDUS–score between baseline and the end of therapy (p<0.001).

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...

Your Unread Messages in Internal Medicine

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Internal Medicine Articles

1 Effects of tea intake on blood pressure: A meta-analysis of 21 randomized controlled trials JACC - Journal of the American College of Cardiology, October 22, 2014    Clinical Article

2 Sweetened carbonated beverage consumption and cancer risk: Meta-analysis and review European Journal of Cancer Prevention, August 1, 2014    Evidence Based Medicine    Review Article

3 Acupuncture for chronic knee pain: a randomized clinical trial JAMA, October 1, 2014    Evidence Based Medicine    Clinical Article

4 Evaluation and treatment of older patients with hypercholesterolemia: A clinical review JAMA, October 20, 2014    Clinical Article

5 Lower versus higher hemoglobin threshold for transfusion in septic shock New England Journal of Medicine, October 7, 2014    Evidence Based Medicine    Clinical Article

6 Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: A mendelian randomisation study The Lancet Diabetes & Endocrinology, October 21, 2014    Clinical Article

7 Comparative effectiveness of pharmacologic treatments to prevent fractures: an updated systematic review Annals of Internal Medicine, September 29, 2014    Evidence Based Medicine    Review Article    Clinical Article

8 Long-term outcomes after stenting versus endarterectomy for treatment of symptomatic carotid stenosis: the International Carotid Stenting Study (ICSS) randomised trial The Lancet, October 16, 2014    Evidence Based Medicine    Clinical Article
Exclusive Author Commentary

9 Total expenditures per patient in hospital-owned and physician-owned physician organizations in California JAMA, October 24, 2014    Evidence Based Medicine    Clinical Article

10 Triglycerides and cardiovascular disease The Lancet, August 19, 2014    Evidence Based Medicine    Clinical Article

11 Nut consumption and the risk of coronary artery disease: A dose–response meta-analysis of 13 prospective studies Thrombosis Research, October 22, 2014    Clinical Article

12 Assessment of the potential for international dissemination of Ebola virus via commercial air travel during the 2014 west African outbreak The Lancet, October 23, 2014    Evidence Based Medicine    Clinical Article

13 Association of fat density with subclinical atherosclerosis Full Text Journal of the American Heart Association, September 19, 2014    Free full text

14 A randomized trial of epidural glucocorticoid injections for spinal stenosis New England Journal of Medicine, July 7, 2014    Evidence Based Medicine    Clinical Article

15 Ivabradine in stable coronary artery disease without clinical heart failure New England Journal of Medicine, September 2, 2014    Evidence Based Medicine    Clinical Article

16 Livebirth after uterus transplantation The Lancet, October 9, 2014    Evidence Based Medicine    Clinical Article

17 Exercises to improve function of the rheumatoid hand (SARAH): a randomised controlled trial The Lancet, October 14, 2014    Evidence Based Medicine    Clinical Article

18 Plasma triglycerides predict ten-years all-cause mortality in outpatients with type 2 diabetes mellitus: a longitudinal observational study Full Text Cardiovascular Diabetology, October 17, 2014    Free full text    Clinical Article

19 Readmissions after hospitalization for heart failure, acute myocardial infarction, or pneumonia among young and middle-aged adults: a retrospective observational cohort study Full Text PLoS Medicine, October 3, 2014    Free full text    Evidence Based Medicine    Clinical Article

20 The influence of whole grain products and red meat on intestinal microbiota composition in normal weight adults: A randomized crossover intervention trial PLOS ONE, October 22, 2014    Clinical Article

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicinemore