Sonographic criteria for therapy follow-up in the course of ultrasound-guided intra-articular injections of hyaluronic acid in hand osteoarthritis
European Journal of Radiology,  Clinical Article

Klauser AS et al. – In this study, the authors demonstrate the meaningfulness of sonographic evaluation criteria including measurements of joint capsule distension and Power–Doppler ultrasound (US) (PDUS) vascularization, both significantly correlating with the decrease of pain, during the therapy follow–up of US–guided intra–articular hyaluronic acid (HA)–injections in patients with hand osteoarthritis (OA).

Methods
  • Thirty–three patients (28 females/5 males), with hand OA in 78 joints, were included in this study.
  • Patients underwent sonographic evaluation at baseline and consecutively for 4 weeks at weekly US–guided intra–articular injections of HA (Hyalgan).
  • Measurements of joint thickening and joint inflammation were performed with Grey–scale and semi–quantitative Power–Doppler US (PDUS).
  • Sonographic values were correlated with weekly patients self–assessment of pain for each treated joint.

Results
  • The mean (SD) patients self–assessment of pain statistically significantly (p<0.0001) decreased from the first [68.3(22.3)] to the last week [37.3(30.34)].
  • A steady pain relief could be noticed in 67 (86%) of all treated joints.
  • Over the whole observation period, the mean (SD) joint thickening of all joints markedly decreased from 15.6mm (5.3) to 13.1mm (6.4) (p<0.0001).
  • The PDUS–score before initiation of HA treatment was statistically significantly higher than at the end of therapy (p<0.0001).
  • The decrease in pain statistically significantly correlated with the decrease of joint thickening and PDUS–score between baseline and the end of therapy (p<0.001).

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Internal Medicine

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Internal Medicine Articles

1 Sweetened carbonated beverage consumption and cancer risk: Meta-analysis and review European Journal of Cancer Prevention, August 1, 2014    Evidence Based Medicine    Review Article

2 A randomized trial of epidural glucocorticoid injections for spinal stenosis New England Journal of Medicine, July 7, 2014    Evidence Based Medicine    Clinical Article

3 Triglycerides and cardiovascular disease The Lancet, August 19, 2014    Evidence Based Medicine    Clinical Article

4 Atrial fibrillation and incident myocardial infarction JAMA, September 16, 2014    Evidence Based Medicine    Clinical Article

5 Withdrawal of inhaled glucocorticoids and exacerbations of COPD New England Journal of Medicine, September 12, 2014    Evidence Based Medicine    Clinical Article

6 Morning blood pressure surge is associated with serum gamma-glutamyltransferase activity in essential hypertensive patients Journal of Human Hypertension, August 29, 2014    Clinical Article

7 Serum gamma-glutamyltransferase levels predict the progression of coronary artery calcification in adults with type 2 diabetes mellitus Angiology, September 3, 2014    Evidence Based Medicine    Clinical Article

8 Follow-up of blood-pressure lowering and glucose control in type 2 diabetes New England Journal of Medicine, September 23, 2014    Evidence Based Medicine    Clinical Article

9 Effect of BCG vaccination against Mycobacterium tuberculosis infection in children: systematic review and meta-analysis BMJ, August 20, 2014    Evidence Based Medicine    Clinical Article

10 A very low carbohydrate, low saturated fat diet for type 2 diabetes management: a randomized trial Diabetes Care, July 31, 2014    Clinical Article

11 Ivabradine in stable coronary artery disease without clinical heart failure New England Journal of Medicine, September 2, 2014    Evidence Based Medicine    Clinical Article

12 Glucagon-like peptide-1 receptor agonist and basal insulin combination treatment for the management of type 2 diabetes: a systematic review and meta-analysis The Lancet, September 15, 2014    Evidence Based Medicine    Clinical Article

13 Ultrasonography versus computed tomography for suspected nephrolithiasis New England Journal of Medicine, September 19, 2014    Evidence Based Medicine    Clinical Article
Exclusive Author Commentary

14 Perioperative atrial fibrillation and the long-term risk of ischemic stroke JAMA, August 26, 2014    Evidence Based Medicine    Clinical Article

15 High risk of failing eradication of Helicobacter pylori in patients with diabetes: A meta-analysis Diabetes Research and Clinical Practice, August 18, 2014    Review Article

16 Management of persistent pain in the older patient: A clinical review JAMA, September 10, 2014    Clinical Article

17 Effects of intensive glycaemic control on ischaemic heart disease: analysis of data from the randomised, controlled ACCORD trial The Lancet, August 5, 2014    Evidence Based Medicine    Clinical Article

18 Quality-of-life outcomes with coronary artery bypass graft surgery in ischemic left ventricular dysfunction: a randomized trial Annals of Internal Medicine, September 25, 2014    Evidence Based Medicine    Clinical Article

19 Relationship between tea consumption and pancreatic cancer risk: A meta-analysis based on prospective cohort studies and case-control studies European Journal of Cancer Prevention, August 1, 2014    Evidence Based Medicine    Clinical Article

20 Ebola virus disease in West Africa -- the first 9 months of the epidemic and forward projections New England Journal of Medicine, September 24, 2014    Evidence Based Medicine    Clinical Article

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicinemore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close