Experimental Induction of Paromomycin Resistance in Antimony-Resistant Strains of L. donovani: Outcome Dependent on In Vitro Selection Protocol

PLoS Neglected Tropical Diseases, 05/30/2012

The resistance proved to be stable. We could clearly demonstrate that a different PMM–resistance is obtained dependent on the ‘stage–selection’ protocol. These findings have important relevance to resistance mechanism investigations and the likelihood of resistance development and detection in the field.

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