Structure, development and function of tertiary lymphoid organs in infection and autoimmunity
Trends in Immunology, 05/25/2012
Neyt K et al. – The lymph nodes (LNs) and spleen have an optimal structure that allows the interaction between T cells, B cells and antigen–presenting dendritic cells (DCs) on a matrix made up by stromal cells. Such a highly organized structure can also be formed in tertiary lymphoid organs (TLOs) at sites of infection or chronic immune stimulation.