OnabotulinumtoxinA Dose-Ranging Study for Hyperdynamic Perioral Lines
Dermatologic Surgery, 06/14/2012
Cohen JL et al. – OnabotulinumtoxinA provides significant reductions in perioral lines (POLs) severity and high levels of subject satisfaction. Lack of dose response and fewer adverse events (AEs) suggest that treatment of hyperdynamic POLs with 7.5 U appears adequate for up to 16 weeks.