The 9p21 coronary artery disease locus and kidney dysfunction in patients with Type 2 diabetes mellitus
Nephrology Dialysis Transplantation, 05/24/2012
De Cosmo S et al. – Variability at the 9p21 coronary artery disease (CAD) locus is unlikely to play a role in modulating susceptibility to kidney dysfunction in patients with Type 2 diabetes mellitus (T2DM).Methods
- Four samples, including a total of 3167 patients, were studied.
- The presence of low eGFR (<60 mL/min/1.73m2) was estimated from serum creatinine by means of the Modification of Diet in Renal Disease Study equation.
- Increased urinary albumin excretion was defined as an albumin–creatinine ratio (ACR) ≥2.5 mg/mmol in men and ≥3.5 mg/mmol in women.
- No association was found between rs2383206 and low eGFR or increased ACR in each sample as well as in a pooled analysis (overall odds ratio = 1.07, 95% confidence interval 0.94–1.22, P = 0.31 and overall odds ratio = 1.00, 95% confidence interval 0.90–1.12, P = 0.95, respectively).
- No interaction was observed between rs2383206 and poor glycemic control [HbA1c was above the median in the pooled sample (7.7%) in modulating eGFR or ACR (P for interaction = 0.42 and 0.90, respectively)].