Sensitivity and specificity of Addenbrooke’s Cognitive Examination, Mattis Dementia Rating Scale, Frontal Assessment Battery and Mini Mental State Examination for diagnosing dementia in Parkinson’s disease
Parkinsonism & Related Disorders, 06/12/2012
Kaszas B et al. – Although the types of applied screening instruments might differ from movement disorder clinic to clinic within a country, determination of the most specific and sensitive test for the given population remains to be an important task. The results demonstrated that the specificity and sensitivity of Mattis Dementia Rating Scale (MDRS was better than those of Addenbrooke’s Cognitive Examination (ACE), Frontal Assessment Battery (FAB) and MMSE in Hungary. However, further studies with larger sample size and more uniform criteria for participation are required to determine the most suitable screening instrument for cognitive impairment.Methods
- In the study the authors evaluated the sensitivity and specificity of different neuropsychological tests (Addenbrooke’s Cognitive Examination, ACE; Frontal Assessment Battery, FAB and Mattis Dementia Rating Scale, MDRS) in 73 Parkinson’s disease patients without depression.
- By receiver operating characteristic curve analysis, these screening instruments were tested against the recently established clinical diagnostic criteria of PDD.
- Best cut-off score for ACE to identify PDD was 80 points (sensitivity=74.0%, specificity=78.1%).
- For FAB the most optimal cut-off value was 12 points (sensitivity=66.3%, specificity=72.2%); whereas for MDRS it was 125 points (sensitivity=89.8%, specificity=98.3%).
- Among the examined test batteries, MDRS had the best clinicometric profile for detecting PDD.