Endogenous cortisol is associated with functional connectivity between the amygdala and medial prefrontal cortex

Psychoneuroendocrinology, 05/25/2012

The results corroborate previous findings from both animal and human studies, suggesting cortisol–mediated regulation of the amygdala by the medial prefrontal cortex. The authors propose that through this feedback mechanism the stress response might be adjusted, pointing to the putative role of cortisol in modulating stress– and, more generally, emotional responses.

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