Postrepolarization refractoriness in acute ischemia and after antiarrhythmic drug administration: Action potential duration is not always an index of the refractory period
Heart Rhythm, 05/25/2012
Coronel R et al. – The findings showed that although postrepolarization refractoriness is profoundly proarrhythmic during ischemia, it may protect the heart from reentrant arrhythmias in the absence of depolarization of the resting membrane. An increase in postrepolarization refractoriness induced by sodium–channel–blocking drugs may exert an antifibrillatory action.