Whole blood flow cytometry measurements of in vivo platelet activation in critically-Ill patients are influenced by variability in blood sampling techniques
Thrombosis Research, 06/01/2012
Rondina MT et al. – In critically–ill patients, variability in vascular sampling site, processing times, and platelet counts influence levels of platelet–monocyte aggregates (PMA), but not PAC–1 binding or P–SEL expression. These data demonstrate the need for rigorous adherence to blood sampling protocols, particularly when levels of PMA, which are most sensitive to variations in blood collection, are measured for detection of in vivo platelet activation.