Moleres A et al. – The genetic predisposition score (GPS) seems to have an important relationship with BMI–SDS and fat mass both at baseline and after a 3–month weight loss lifestyle intervention. Obese and overweight adolescents with a lower GPS have a greater benefit of weight loss after 3 months of a multidisciplinary lifestyle intervention.Methods
- Overweight/obese adolescents (n = 168; 12-16 years) participating in the EVASYON program were genotyped for 9 obesity-related single nucleotide polymorphisms in the FTO, MC4R, TMEM18, IL6, PPARG, and ADIPQ genes.
- At baseline, the GPS showed a significant association with body mass index-standard deviation score (BMI-SDS) and fat mass.
- After 3 months of intervention, this GPS also showed a relationship with the variation of both anthropometric measurements.
- After adjusting for baseline BMI-SDS, subjects with a lower GPS had a greater improvement on metabolic profile, as well as a better response to physical activity, compared with those subjects with a higher GPS.