The IFN signature and STAT1 expression in RA synovial fluid macrophages are induced by TNFα and counter-regulated by synovial fluid microenvironment
Arthritis & Rheumatism, 06/04/2012
Gordon RA et al. – The findings identify a new function for TNFα in RA synovitis by implicating TNFα as a major inducer of the RA synovial IFN response. The results suggest that the expression of IFN response genes in RA synovium is regulated by interplay between TNFα and opposing homeostatic factors expressed in the synovial microenvironment.