Tumor-Expressed Inducible Nitric Oxide Synthase Controls Induction of Functional Myeloid-Derived Suppressor Cells through Modulation of Vascular Endothelial Growth Factor Release
The Journal of Immunology, 05/24/2012
Jayaraman P et al. – The data suggest a critical role for tumor–expressed inducible NO synthase (iNOS) in the recruitment and induction of functional MDSC by modulation of tumor vascular endothelial growth factor (VEGF) secretion and upregulation of STAT3 and ROS in myeloid–derived suppressor cell (MDSC).



