Two Preferentially Expressed Proteins Protect Vascular Endothelial Cells from an Attack by Peptide-Specific CTL
The Journal of Immunology, 05/24/2012
Thommen DS et al. – The authors conclude that EC express and present preferentially two distinct HLA–A*02–restricted peptides at extraordinary high levels. These abundant self–peptides may protect EC from CTL–mediated lysis by competing for HLA–A*02 binding sites with immunodominant scarcely expressed antigenic peptides.