Human proximal tubule epithelial cells modulate autologous dendritic cell function
Nephrology Dialysis Transplantation, 05/21/2012
Kassianos AJ et al. – The authors' data suggest that activated proximal tubule epithelial cells (PTEC) regulate human autologous immunity via complex interactions with dendritic cells (DC). The ability of PTEC to modulate autologous DC function has important implications for the dampening of pro–inflammatory immune responses within the tubulointerstitium in renal injuries. Further dissection of the mechanisms of PTEC modulation of autologous immune responses may offer targets for therapeutic intervention in renal medicine.