Interaction between the intestinal microbiota and host in Clostridium difficile colonization resistance
Trends in Microbiology, 05/25/2012
Britton RA et al. – Although previous use of antibiotics is generally considered to be the sine qua non of CDI, the mechanisms by which antibiotics render the host susceptible to C. difficile are not well defined. In this review, they will explore what is known about how the indigenous microbiota acts in concert with the host to prevent colonization and virulence of C. difficile and how antibiotic administration disturbs host–microbiota homeostasis, leading to CDI.