Alphaherpesvirus infection disrupts mitochondrial transport in neurons
Cell Host & Microbe, 05/25/2012
Kramer T et al. – Consequently, intracellular [Ca2+] increases and alters mitochondrial dynamics through a mechanism involving the Ca2+–sensitive cellular protein Miro and reduced recruitment of kinesin–1 to mitochondria. This disruption in mitochondrial dynamics is required for efficient growth and spread of PRV, indicating that altered mitochondrial transport enhances alphaherpesvirus pathogenesis and infection.