Emergence of distinct multiarmed immunoregulatory antigen-presenting cells during persistent viral infection
Cell Host & Microbe, 05/30/2012
Wilson EB et al. – Characterization demonstrates that immunoregulatory APCs are molecularly and metabolically distinct, and exhibit increased expression of T cell–interacting molecules and negative regulatory factors that suppress T cell responses. Thus, immunoregulatory APCs are amplified during viral persistence and deliver inhibitory signals that suppress antiviral T cell immunity and likely contribute to persistent infection.