KIAA1549-BRAF fusions and IDH mutations can coexist in diffuse gliomas of adults
Brain Pathology, 05/24/2012
Badiali M et al. – The results suggest that in a small fraction of diffuse gliomas, KIAA1549–BRAF fusion gene and BRAFv600E mutation may be responsible for deregulation of the Ras–RAF–ERK signaling pathway. Such alterations are more frequent in oligodendroglial neoplasm and may be co–present with IDH mutations and 1p/19q loss.