mdlinx mdlinx
Latest (288) Full Text Articles (9654) Focus on GERD & PUD Article Summary

Meta-analysis of dietary glycemic load and glycemic index in relation to risk of coronary heart disease
The American Journal of Cardiology,

Dong JY et al. – High dietary GL and GI significantly increased the risk of CHD in women but not in men, and the unfavorable effects may be more pronounced in overweight and obese patients. Further studies are needed to verify these findings and elucidate the underlying mechanisms.

  • A high glycemic diet may increase cardiovascular risk, yet whether the risk differs by gender or adiposity is inconclusive.
  • These goal was to determine the associations between dietary glycemic load (GL) and glycemic index (GI), and coronary heart disease (CHD) risk by conducting a meta–analysis of prospective studies.
  • Authors searched the PubMed and Embase databases in July 2011 to identify eligible studies.
  • The random–effects model was used to calculate pooled relative risks (RRs) comparing the highest categories of exposure to the lowest. Prespecified subgroup analyses were performed by gender and body mass index.
  • Authors identified 8 prospective studies for meta–analysis, consisting of 220,050 participants and 4,826 incident CHD cases.
  • Pooled RRs of CHD in relation to dietary GL were 1.08 (95% confidence interval [CI] 0.92 to 1.27) for men, 1.69 (95% CI 1.32 to 2.16) for women, and 1.36 (95% CI 1.13 to 1.63) for men and women combined.
  • For dietary GI, corresponding pooled RRs were 0.99 (95% CI 0.84 to 1.16), 1.26 (95% CI 1.12 to 1.43), and 1.13 (95% CI 1.00 to 1.28), respectively.
  • Limited evidence suggested the associations appeared more evident in the overweight and obese.
  • There was no indication of publication bias.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Internal Medicine

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Internal Medicine Articles

Last month's top read Top Articles of 2013

1 Is ginger effective for the treatment of irritable bowel syndrome? A double blind randomized controlled pilot trial Complementary Therapies in Medicine, March 4, 2014    Clinical Article

2 Tea consumption and leukemia risk: A meta-analysis Tumor Biology, February 12, 2014    Evidence Based Medicine    Clinical Article

3 Animal protein intake is associated with higher-level functional capacity in elderly adults: The Ohasama study Journal of the American Geriatrics Society, March 5, 2014    Clinical Article

4 Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial The Lancet, March 19, 2014    Evidence Based Medicine    Clinical Article

5 Glycated hemoglobin measurement and prediction of cardiovascular disease JAMA, March 26, 2014    Evidence Based Medicine

6 Association of {beta}-blocker therapy with risks of adverse cardiovascular events and deaths in patients with ischemic heart disease undergoing noncardiac surgery: A Danish nationwide cohort study JAMA Internal Medicine, March 11, 2014    Evidence Based Medicine    Clinical Article

7 Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: The ADJUST-PE study JAMA, March 20, 2014    Evidence Based Medicine    Clinical Article

8 Mortality from ruptured abdominal aortic aneurysms: clinical lessons from a comparison of outcomes in England and the USA The Lancet, March 17, 2014    Evidence Based Medicine    Clinical Article

9 Obstructive sleep apnea and risk of cardiovascular events and all-cause mortality: A decade-long historical cohort study Full Text PLoS Medicine, February 7, 2014    Free full text    Evidence Based Medicine    Clinical Article

10 Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials The Lancet, March 24, 2014    Evidence Based Medicine    Clinical Article

11 Multitarget stool DNA testing for colorectal-cancer screening New England Journal of Medicine, March 21, 2014    Evidence Based Medicine    Clinical Article

12 Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis The Lancet, October 11, 2013    Evidence Based Medicine    Clinical Article

13 Dietary carrot consumption and the risk of prostate cancer European Journal of Nutrition, February 17, 2014    Clinical Article

14 Treatment of venous thromboembolism JAMA, February 19, 2014    Evidence Based Medicine    Clinical Article

15 Serum levels of fetuin-A, osteoprotegerin and osteopontin in patients with coronary artery disease: Effects of Statin (HMGCoA-Reductase Inhibitor) Therapy Clinical Drug Investigation, March 3, 2014    Clinical Article

16 Effects of music on complications during hemodialysis for chronic renal failure patients Hemodialysis International, March 27, 2014    Clinical Article

17 Egg consumption and risk of GI neoplasms: dose–response meta-analysis and systematic review European Journal of Nutrition, February 6, 2014    Evidence Based Medicine    Review Article

18 Effect of omega-3 fatty acid supplementation on cancer incidence, non-vascular death, and total mortality: a meta-analysis of randomized controlled trials Full Text BMC Public Health, March 5, 2014    Free full text    Evidence Based Medicine    Clinical Article

19 Screening for prostate cancer with the prostate-specific antigen test: A review of current evidence JAMA, March 20, 2014    Evidence Based Medicine    Clinical Article

20 Effects of spironolactone on long-term mortality and morbidity in patients with heart failure and mild or no symptoms The American Journal of the Medical Sciences, March 25, 2014    Evidence Based Medicine    Clinical Article

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicinemore

Other Topics in Internal Medicine

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Stay current - Media Tool

Newsletter
RSS
Follow
Like

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close