Intraoperative autologous blood transfusion use during radical hysterectomy for cervical cancer: long-term follow-up of a prospective trial
Archives of Gynecology and Obstetrics,
Engle DB et al. – Autologous blood transfusion during radical hysterectomy for cervical cancer appears safe and effective.Methods
- The institution published a prospective cohort study examining the use of ABT in cervical cancer patients undergoing radical hysterectomy in 1995.
- Patients who were initially consented to participate in this prospective trial using intraoperative ABT (cell saver) were evaluated with a median follow–up of 3 years.
- Authors sought to update this original report with 16–year follow–up data collected from the clinical charts, Tumor Registry, and the Social Security Death Index.
- Two groups of patients undergoing radical hysterectomy were compared: patients who received ABT, and those who did not.
- Of the 71 original patients, all were included in this updated review, with an average follow–up of 12.4 years for both groups.
- Originally, thirty–one patients received an ABT.
- In this group, 1 patient was lost to follow–up, and 4 (12.9 %) are deceased including 1 (3 %) with disease.
- In the non–autologous group, there were 7 (17.5 %) patient deaths, including 3 (7.5 %) with disease.
- Eighty–three percent were alive after 12 years in both groups.
- The ABT group had 1 patient (3 %) who developed a secondary malignancy, a colon adenocarcinoma.
- The non–autologous group had 2 patients (5 %) who developed a secondary malignancy; one patient developed multiple myeloma and one patient developed a verrucous cancer of the tongue.