Mechanistic correlations between two itch biomarkers, IL-31 cytokine and beta-endorphin neuropeptide, via STAT3/calcium axis in atopic dermatitis
British Journal of Dermatology, 05/17/2012
Lee CH et al. – The authors concluded IL–31R activation in keratinocytes induced calcium influx and STAT3–dependent production of beta–endorphin. These results might contribute to an understanding of regulatory mechanisms underlying peripheral itch.