Ivacaftor potentiation of multiple CFTR channels with gating mutations
Journal of Cystic Fibrosis, 05/24/2012
Yu H et al. – The in vitro data suggest that ivacaftor has a similar effect on all CFTR forms with gating defects and support investigation of the potential clinical benefit of ivacaftor in CF patients who have CFTR gating mutations beyond G551D.



