Maturation defective myeloid dendritic cells in nonalcoholic fatty liver disease patients release inflammatory cytokines in response to endotoxin
Hepatology International, 05/30/2012
Rana D et al. – The results indicate that dendritic cells (DCs) in patients with Nonalcoholic fatty liver disease (NAFLD) exhibit immature yet functionally activated phenotype in response to LPS stimulation as they secrete inflammatory cytokines which further contribute in exacerbating the symptoms. Inefficient antigen presentation in these patients might add another parameter while looking at the severity of disease.