The significance of low PU.1 expression in patients with acute promyelocytic leukemia
Journal of Hematology & Oncology, 05/11/2012
Zhu X et al. – The results showed that PU.1 expression was lower in patients with APL than other acute myeloid leukemia (AML) subtypes and there was also a trend towards increasing PU.1 expression from AML–M0 to AML–M5, with the exception of AML–M3 (APL). These observations suggested that PU.1 expression was reduced by PML–RARalpha in APL patients.