Circadian Disruption, Sleep Loss and Prostate Cancer Risk: A Systematic Review of Epidemiological Studies
Cancer Epidemiology, Biomarkers & Prevention, 05/21/2012
Evidence Based Medicine
Sigurdardottir LG et al. – Disruption of the circadian system has been hypothesized to increase cancer risk, either due to direct disruption of the molecular machinery generating circadian rhythms or due to disruption of parameters controlled by the clock such as melatonin levels or sleep duration. This hypothesis has been studied in hormone–dependent cancers among women, but data are sparse regarding potential effects of circadian disruption on the risk of prostate cancer.