Replication Study and Meta-Analysis in European Samples Supports Association of the 3p21.1 Locus with Bipolar Disorder
Biological Psychiatry, 05/08/2012
Evidence Based Medicine
Vassos E et al. – There is strong evidence of association of rs2251219 with bipolar affective disorder. However, the authors' data do not support association of this marker with schizophrenia. Because the region of association has high linkage disequilibrium, forming a large haplotype block across many genes, it is not clear which gene is causally implicated in the disorder.