Effect of Vitamin C Administration on Leukocyte Vitamin C Level and Severity of Bronchial Asthma

Acta Medica Iranica, 05/09/2012

In group A, who received 1000 mg/day vitamin C, none of the spirometry parameters changed after one month treatment, indicating no effect of vitamin C treatment in the spirometry parameters.


  • In this double blind clinical trial study we evaluated 60 patients with chronic stable asthma.
  • The patients were divided into two groups (A and B) including 30 patients in each group.
  • Patients in these groups were matched according to their age, weight, height, gender, BMI and drug consumption.
  • In addition to standard asthma treatment (according to stepwise therapy in 4th step of bronchial asthma) in which the patients were controlled appropriately, group A received 1000 mg vitamin C daily and group B received placebo.


  • At the baseline and after one month treatment, non–fasting blood samples were drawn for laboratory evaluations.
  • Asthmatic patient's clinical condition was evaluated through standard pulmonary function test (PFT).
  • The mean (±SD) leukocyte vitamin C level in group A at the baseline and after one month treatment with 1000 mg/day vitamin C, were 0.0903 (±0.0787) µg/108 leukocytes and 0.1400 (±0.0953) µg/108 leukocytes respectively (P<0.05).
  • The mean (±SD) leukocyte vitamin C level in group B at the baseline and after one month administration of placebo, were 0.0867 (±0.0629) µg/108 leukocytes and 0.0805(±0.0736) µg/108 leukocytes respectively.
  • The leukocyte vitamin C level in group A was higher than those of group B after one month treatment with vitamin C and placebo and the difference was statistically significant (P<0.05).
  • Comparing PFT (FEV1, FVC and FEV1/FVC) in group B during the study period showed a significant increase in FEV1 (P<0.05), while the other two parameters remained unchanged.

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