Increased oxidative DNA damage and impaired antioxidant defense system in patients with gastrointestinal cancer
European Journal of Internal Medicine , 05/09/2012
Gönenc A et al. – The results demonstrate that the oxidant/antioxidant balance was altered in favor of free radicals and DNA damage in gastrointestinal cancer patients. Significant increases in 8–hydroxy–deoxyguanosine, glutathione and decreases in nitrite+nitrate, SOD, CAT activities and antioxidant molecules suggest the possible involvement of oxidative stress in gastrointestinal cancer. Glutathione peroxidase activities in postoperative patients were higher compared to inoperative patients.