Association of vitamin D with cardiometabolic risk factors in rheumatoid arthritis
Arthritis Care & Research , 05/08/2012
Haque UJ et al. – These data suggest that vitamin D deficiency is common in rheumatoid arthritis (RA) and may be independently associated with several cardiometabolic intermediates in this population.Methods
- Serum 25(OH)D levels were measured among RA patients enrolled in a cohort study of subclinical CVD.
- The cross–sectional associations of 25(OH)D level with traditional CVD risk factors, such as insulin resistance [estimated using the Homeostatic Model Assessment (HOMA)], adiopokines, markers of systemic inflammation and endothelial activation were explored, adjusting for pertinent sociodemographic, lifestyle, and RA characteristics.
- Among 179 RA patients, 73 (41%) had a 25(OH)D level <30ng/mL.
- Only 23 patients (13%) had a 25(OH)D level ≥45ng/mL.
- After adjusting for demographics and BMI, 25(OH)D remained significantly associated with HDL and inversely associated with HOMA–IR, fibrinogen, E–selectin, and s–ICAM.
- Significant associations with HDL, E–selectin, and s–ICAM were maintained after adjusting for DAS28 and autoantibody status.
- These associations were similar between groups subdivided by gender, ethnicity, body mass index, DAS28 level and autoantibody status.