Group I nonreciprocal inhibition in restless legs syndrome secondary to chronic renal failure
Parkinsonism & Related Disorders, 05/18/2012
Marconi S et al. – Unlike primary restless legs syndrome (p–RLS) patients, Uremic RLS (u–RLS) patients had normal I nonreciprocal (Ib) inhibition, suggesting a regular supraspinal control of Ib spinal interneurons. Subclinical peripheral nerve abnormalities were detected in most uremic patients. Peripherally disrupted sensory modulation may represent the major pathophysiological determinant of uremic RLS.