Naltrexone Modification of Drinking Effects in a Subacute Treatment and Bar-Lab Paradigm: Influence of OPRM1 and Dopamine Transporter (SLC6A3) Genes
Alcoholism: Clinical and Experimental Research,  Clinical Article

Anton RF et al. – This study does not support a salient role for the opioid receptor (OPRM1) asp40 alone in predicting drinking or naltrexone effects. However, although exploratory and in need of replication, it introduces the possibility that epistasis between the OPRM1 gene and dopamine transporter gene might need to be taken into account when examining differential genetic response to alcohol or medication treatment, especially in early–stage alcoholics.

Methods
  • Two hundred and sixty-five nontreatment-seeking individuals with alcohol dependence were genotyped a priori for the OPRM1 asn40asp SNP and post hoc for DAT (SLC6A3) 9 and 10 VNTRs.
  • Asp40 carriers (n = 43) and matched asn40 homozygotes (n = 40) were randomized to naltrexone or placebo for 7 days before receiving a priming drink and limited-access alcohol consumption in a bar-lab setting.
  • Effects of genotypes on natural drinking as well as drinking, alcohol effects, and response to naltrexone in the bar-lab setting were examined by genotype.

Results
  • There were no significant main effects of naltrexone or OPRM1 genotype, or any medication by OPRM1 interaction, on drinking variables.
  • However, in individuals who had at least one DAT 9 VNTR, and who were also OPRM1 asn40 homozygotes, naltrexone reduced drinks/d consumed under natural conditions (p = 0.006), but not in the bar-lab.
  • OPRM1 asn40 homozygotes (p = 0.028) and DAT 9 VNTR carriers (p = 0.032) had more stimulation to alcohol after the priming drink.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Internal Medicine

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Internal Medicine Articles

1 Sweetened carbonated beverage consumption and cancer risk: Meta-analysis and review European Journal of Cancer Prevention, August 1, 2014    Evidence Based Medicine    Review Article

2 A randomized trial of epidural glucocorticoid injections for spinal stenosis New England Journal of Medicine, July 7, 2014    Evidence Based Medicine    Clinical Article

3 Triglycerides and cardiovascular disease The Lancet, August 19, 2014    Evidence Based Medicine    Clinical Article

4 Atrial fibrillation and incident myocardial infarction JAMA, September 16, 2014    Evidence Based Medicine    Clinical Article

5 Withdrawal of inhaled glucocorticoids and exacerbations of COPD New England Journal of Medicine, September 12, 2014    Evidence Based Medicine    Clinical Article

6 Morning blood pressure surge is associated with serum gamma-glutamyltransferase activity in essential hypertensive patients Journal of Human Hypertension, August 29, 2014    Clinical Article

7 Serum gamma-glutamyltransferase levels predict the progression of coronary artery calcification in adults with type 2 diabetes mellitus Angiology, September 3, 2014    Evidence Based Medicine    Clinical Article

8 Follow-up of blood-pressure lowering and glucose control in type 2 diabetes New England Journal of Medicine, September 23, 2014    Evidence Based Medicine    Clinical Article

9 Effect of BCG vaccination against Mycobacterium tuberculosis infection in children: systematic review and meta-analysis BMJ, August 20, 2014    Evidence Based Medicine    Clinical Article

10 A very low carbohydrate, low saturated fat diet for type 2 diabetes management: a randomized trial Diabetes Care, July 31, 2014    Clinical Article

11 Ivabradine in stable coronary artery disease without clinical heart failure New England Journal of Medicine, September 2, 2014    Evidence Based Medicine    Clinical Article

12 Glucagon-like peptide-1 receptor agonist and basal insulin combination treatment for the management of type 2 diabetes: a systematic review and meta-analysis The Lancet, September 15, 2014    Evidence Based Medicine    Clinical Article

13 Ultrasonography versus computed tomography for suspected nephrolithiasis New England Journal of Medicine, September 19, 2014    Evidence Based Medicine    Clinical Article
Exclusive Author Commentary

14 Perioperative atrial fibrillation and the long-term risk of ischemic stroke JAMA, August 26, 2014    Evidence Based Medicine    Clinical Article

15 High risk of failing eradication of Helicobacter pylori in patients with diabetes: A meta-analysis Diabetes Research and Clinical Practice, August 18, 2014    Review Article

16 Management of persistent pain in the older patient: A clinical review JAMA, September 10, 2014    Clinical Article

17 Effects of intensive glycaemic control on ischaemic heart disease: analysis of data from the randomised, controlled ACCORD trial The Lancet, August 5, 2014    Evidence Based Medicine    Clinical Article

18 Quality-of-life outcomes with coronary artery bypass graft surgery in ischemic left ventricular dysfunction: a randomized trial Annals of Internal Medicine, September 25, 2014    Evidence Based Medicine    Clinical Article

19 Relationship between tea consumption and pancreatic cancer risk: A meta-analysis based on prospective cohort studies and case-control studies European Journal of Cancer Prevention, August 1, 2014    Evidence Based Medicine    Clinical Article

20 Ebola virus disease in West Africa -- the first 9 months of the epidemic and forward projections New England Journal of Medicine, September 24, 2014    Evidence Based Medicine    Clinical Article

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicinemore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close