A moderate weight reduction through dietary intervention decreases hepatic fat content in patients with non-alcoholic fatty liver disease (NAFLD): a pilot study
European Journal of Nutrition, 05/01/2012
Volynets V et al. – The results indicate that a dietary intervention focusing only on one dietary parameter like fructose may help to decrease intrahepatic fat content of non–alcoholic fatty liver disease patients.Methods
- A total of 15 patients with NAFLD were enrolled in the study of which 10 finished the study.
- Fructose and total nutrient intake were assessed using a diet history.
- At baseline and after 6 months liver status and markers of intestinal barrier function as well as plasminogen activator inhibitor (PAI–) 1 concentration were determined in plasma.
- Hepatic lipid content and transaminases in plasma as well as body mass index and some parameters of glucose metabolism (e.g., fasting plasma insulin) were significantly lower at the end of the intervention when compared to baseline.
- Whereas the dietary intervention had no effect on the prevalence of bacterial overgrowth, orocecal transit time and the intestinal permeability or blood ethanol levels endotoxin and PAI–1 concentration in plasma were significantly lower at the end of 6 months intervention period than at baseline.