Protracted Withdrawal from Cocaine Self-Administration Flips the Switch on 5-HT1B Receptor Modulation of Cocaine Abuse-Related Behaviors
Biological Psychiatry, 05/03/2012
Pentkowski NS et al. – Mesolimbic serotonin–1B receptors (5–HT1BRs) differentially modulate cocaine abuse–related behaviors, with a facilitative influence during periods of active drug use, in striking contrast to an inhibitory influence during protracted withdrawal. These findings suggest that targeting 5–HT1BRs may lead to a novel treatment for cocaine dependence and that the therapeutic efficacy of these treatments may vary depending on the stage of the addiction cycle.