Flow cytometry in myelodysplastic syndrome: analysis of diagnostic utility using maturation pattern-based and quantitative approaches

Annals of Hematology, 05/09/2012

Used in the overall clinical context, both maturation pattern recognition and quantitative approaches, the latter for low–grade myelodysplastic syndrome (MDS), are sensitive methods of diagnosing MDS, including cases negative by morphology and cytogenetics, especially if combined with evaluation of selected antigens, CD71 on CD235a+ cells and CD38 on CD34+ cells. The value of Flow cytometry (FCM) in morphology–negative cases needs better definition of specificity through more extensive evaluation of secondary dyspoiesis.

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