Urinary interleukin-18 and urinary neutrophil gelatinase-associated lipocalin predict acute kidney injury following pulmonary valve replacement prior to serum creatinine
Congenital Heart Disease, 05/17/2012
Buelow MW et al. – Both neutrophil gelatinase–associated lipocalin (NGAL) and IL–18 are early predictive biomarkers of AKI, and both increase in tandem after surgical pulmonary valve replacement (PVR). Importantly, both rise before an increase in creatinine or a decrease in eGFR is present. Monitoring both biomarkers may allow for earlier detection and subsequent interventions to prevent AKI at time of surgery for congenital heart disease (CHD).