Factor XI: Hemostasis, Thrombosis, and Antithrombosis
Thrombosis Research, 05/03/2012
He R et al. – The new emerging concept of inhibiting Coagulation factor FXI (FXI) as a novel antithrombotic approach with an improved benefit–risk ratio has been supported through observations from human FXI deficiency and various animal models. Large– and small–molecule FXI inhibitors have shown promising antithrombotic effects.