Cyclosporin A and Tacrolimus reduce T-cell polyfunctionality but not IFN- responses directed at Cytomegalovirus

Immunology, 05/17/2012

The proportions of TNF–α+/IFN–γ+/IL2 cells among the activated cells were significantly reduced in transplant patients but not the frequencies of IFN–γ+ CD8+ T–cells. Immunosuppression reduces polyfunctionality which reflects the increased infection risk in this patient group.

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