Blockade of Tim-3 signaling restores the virus-specific CD8+T-cell response in patients with chronic hepatitis B
European Journal of Immunology, 05/11/2012
Wu W et al. – Tim–3+CD8+T cells exhibited proliferative senescence phenotypes and decreased cytokine production upon antigen challenge. Finally, blocking the Tim–3 pathway significantly improved proliferation and antiviral cytokine secretion of CD8+T cells in response to HBV–specific antigen peptides. Tim–3 negatively regulates antiviral responses of CD8+T cells isolated from CHB patients, and this response is reversed by blocking the Tim–3 pathway.