Canagliflozin improves glycaemic control over 28 days in subjects with type 2 diabetes not optimally controlled on insulin
Diabetes, Obesity and Metabolism,  Clinical Article

Devineni D et al. – In subjects receiving insulin and oral antihyperglycaemic therapy, canagliflozin was well tolerated without evidence for glucose malabsorption, had pharmacokinetic characteristics consistent with once–daily dosing, and improved glycaemic control.

Methods
  • This was a randomized, double-blind, placebo-controlled, parallel-group, 28-day study conducted at two sites, in 29 subjects with T2DM not optimally controlled on insulin and up to one oral antihyperglycaemic agent.
  • Subjects were treated with canagliflozin 100 mg QD or 300 mg twice daily (BID) or placebo.
  • Safety, tolerability, pharmacokinetic characteristics and pharmacodynamic effects of canagliflozin were examined.
  • Glucose malabsorption following a 75-g oral glucose challenge was also examined.

Results
  • Canagliflozin pharmacokinetics were dose-dependent, and the elimination half-life ranged from 12 to 15 h.
  • After 28 days, the renal threshold for glucose excretion was reduced; urinary glucose excretion was increased; and A1C, fasting plasma glucose and body weight decreased in subjects administered canagliflozin (A1C reductions: 0.19% with placebo, 0.73% with 100 mg QD, 0.92% with 300 mg BID; body weight changes: 0.03 kg increase with placebo, 0.73 kg reduction with 100 mg QD, 1.19 kg reduction with 300 mg BID).
  • Glucose malabsorption was not observed with canagliflozin treatment.
  • There were no deaths, serious adverse events or severe hypoglycaemic episodes.
  • The incidence of adverse events was similar across groups.
  • There were no clinically meaningful changes in routine laboratory safety tests, vital signs or electrocardiograms.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Internal Medicine

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Internal Medicine Articles

1 Sweetened carbonated beverage consumption and cancer risk: Meta-analysis and review European Journal of Cancer Prevention, August 1, 2014    Evidence Based Medicine    Review Article

2 A randomized trial of epidural glucocorticoid injections for spinal stenosis New England Journal of Medicine, July 7, 2014    Evidence Based Medicine    Clinical Article

3 Triglycerides and cardiovascular disease The Lancet, August 19, 2014    Evidence Based Medicine    Clinical Article

4 Atrial fibrillation and incident myocardial infarction JAMA, September 16, 2014    Evidence Based Medicine    Clinical Article

5 Withdrawal of inhaled glucocorticoids and exacerbations of COPD New England Journal of Medicine, September 12, 2014    Evidence Based Medicine    Clinical Article

6 Morning blood pressure surge is associated with serum gamma-glutamyltransferase activity in essential hypertensive patients Journal of Human Hypertension, August 29, 2014    Clinical Article

7 Serum gamma-glutamyltransferase levels predict the progression of coronary artery calcification in adults with type 2 diabetes mellitus Angiology, September 3, 2014    Evidence Based Medicine    Clinical Article

8 Follow-up of blood-pressure lowering and glucose control in type 2 diabetes New England Journal of Medicine, September 23, 2014    Evidence Based Medicine    Clinical Article

9 Effect of BCG vaccination against Mycobacterium tuberculosis infection in children: systematic review and meta-analysis BMJ, August 20, 2014    Evidence Based Medicine    Clinical Article

10 A very low carbohydrate, low saturated fat diet for type 2 diabetes management: a randomized trial Diabetes Care, July 31, 2014    Clinical Article

11 Ivabradine in stable coronary artery disease without clinical heart failure New England Journal of Medicine, September 2, 2014    Evidence Based Medicine    Clinical Article

12 Glucagon-like peptide-1 receptor agonist and basal insulin combination treatment for the management of type 2 diabetes: a systematic review and meta-analysis The Lancet, September 15, 2014    Evidence Based Medicine    Clinical Article

13 Ultrasonography versus computed tomography for suspected nephrolithiasis New England Journal of Medicine, September 19, 2014    Evidence Based Medicine    Clinical Article
Exclusive Author Commentary

14 Perioperative atrial fibrillation and the long-term risk of ischemic stroke JAMA, August 26, 2014    Evidence Based Medicine    Clinical Article

15 High risk of failing eradication of Helicobacter pylori in patients with diabetes: A meta-analysis Diabetes Research and Clinical Practice, August 18, 2014    Review Article

16 Management of persistent pain in the older patient: A clinical review JAMA, September 10, 2014    Clinical Article

17 Effects of intensive glycaemic control on ischaemic heart disease: analysis of data from the randomised, controlled ACCORD trial The Lancet, August 5, 2014    Evidence Based Medicine    Clinical Article

18 Quality-of-life outcomes with coronary artery bypass graft surgery in ischemic left ventricular dysfunction: a randomized trial Annals of Internal Medicine, September 25, 2014    Evidence Based Medicine    Clinical Article

19 Relationship between tea consumption and pancreatic cancer risk: A meta-analysis based on prospective cohort studies and case-control studies European Journal of Cancer Prevention, August 1, 2014    Evidence Based Medicine    Clinical Article

20 Ebola virus disease in West Africa -- the first 9 months of the epidemic and forward projections New England Journal of Medicine, September 24, 2014    Evidence Based Medicine    Clinical Article

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicinemore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close